it doesn't really fuck you up, just makes you more relaxed i guess. i can't take any of that cold stuff, nyquil anything with tylenol in it, that fucks me up.
When I got my wisdom teeth out they gave me vicodin. I didn't notice anything special about the effects it had. When I forgot to take my pill I wasn't in any great pain so I just assumed it didn't affect me that much or that the dosage was real low.
I hold the dubious honor of being the only person never modded who has also never been to a party who in the past had a shared account with a vegetable reference that has had consensual sex with a woman who wasn't from the board that also knows what >) means and remembers the end of the golden age.