CDIH - The Stoner Forum

I condone drug use.

Tue, 05 Aug 2008 21:50:28 +0000

Just sayin'.

i got high and made this today

Sat, 14 Apr 2007 01:35:38 +0000

http://youtube.com/watch?v=Z59al09IvnM

then i smoked it and got higher.

Amsterdam!

Fri, 09 Feb 2007 16:23:50 +0000

So I'm going to amsterdam in a few weeks and just wanted to see if anyone had any suggestions about places to go and whatnot.

bong mod

Sun, 03 Dec 2006 18:52:46 +0000

http://s134.photobucket.com/albums/q108/reghartner/

i made a light switch for my friends bong. i used a can of cashews, an LED, 2 AA batteries, a little switch, and some duct tape...the end result is sick tits.

shrooms!

Sun, 26 Nov 2006 04:48:58 +0000

I just got 15 grams of shrooms!

Unfortunately, they are dry, so they won't be as good. But I am so excited.

so i tried shrooms a few weeks ago...

Thu, 18 May 2006 05:20:38 +0000

that shit was fucking crazy.

Hey Goatweed...

Sat, 04 Mar 2006 04:07:55 +0000

I just wanted to say that you look really pretty today.

They are back.

Thu, 23 Feb 2006 06:37:52 +0000

See below.

Since Adolf's a toker

Fri, 06 Jan 2006 05:01:46 +0000

I suggest we make a spot for him in the corner of the smoke room.

STONER SPELLING BEE!

Thu, 29 Dec 2005 17:57:03 +0000

the first word is

antidisestablishmententarianism.

Danked Does Amsterdam (& Paris)! - 2006

Mon, 14 Nov 2005 20:01:20 +0000

I shall be returning to Amsterdam sometime in April during my European vacation with friends.

And you're all invited!

Let's make it a board party to forget to remember!

GROOVY

Thu, 03 Nov 2005 19:14:18 +0000

GROOVY

Pot not a major cancer risk - Someone's gotta keep this forum alive

Fri, 28 Oct 2005 16:18:21 +0000

Good news

Pot not a major cancer risk: report By Amy Norton
Wed Oct 26,12:29 PM ET

NEW YORK (Reuters Health) - Although both marijuana and tobacco smoke are packed with cancer-causing chemicals, other qualities of marijuana seem to keep it from promoting lung cancer, according to a new report.

The difference rests in the often opposing actions of the nicotine in tobacco and the active ingredient, THC, in marijuana, says Dr. Robert Melamede of the University of Colorado in Colorado Springs.

He reviewed the scientific evidence supporting this contention in a recent issue of Harm Reduction Journal.

Whereas nicotine has several effects that promote lung and other types of cancer, THC acts in ways that counter the cancer-causing chemicals in marijuana smoke, Melamede explained in an interview with Reuters Health.

"THC turns down the carcinogenic potential," he said.

For example, lab research indicates that nicotine activates a body enzyme that converts certain chemicals in both tobacco and marijuana smoke into cancer-promoting form. In contrast, studies in mice suggest that THC blocks this enzyme activity.

Another key difference, Melamede said, is in the immune system effects of tobacco and marijuana. Smoke sends irritants into the respiratory system that trigger an immune-regulated inflammatory response, which involves the generation of potentially cell-damaging substances called free radicals. These particles are believed to contribute to a range of diseases, including cancer.

But cannabinoids -- both those found in marijuana and the versions found naturally in the body -- have been shown to dial down this inflammatory response, Melamede explained.

Another difference between tobacco and marijuana smoking, he said, has to do with cells that line the respiratory tract. While these cells have receptors that act as docks for nicotine, similar receptors for THC and other cannabinoids have not been found.

Nicotine, Melamede said, appears to keep these cells from committing "suicide" when they are genetically damaged, by smoking, for instance. When such cells do not kill themselves off, they are free to progress into tumors.

THC, however, does not appear to act this way in the respiratory tract -- though, in the brain, where there are cannabinoid receptors, it may have the beneficial effect of protecting cells from death when they are damaged from an injury or stroke, according to Melamede.

All of this, he said, fits in with population studies that have failed to link marijuana smoking with a higher risk of lung cancer -- though there is evidence that pot users have more respiratory problems, such as chronic cough and frequent respiratory infections.

If marijuana does not promote lung cancer, that could factor into the ongoing debate over so-called medical marijuana. Melamede said he believes "marijuana has loads of medicinal value," for everything from multiple sclerosis, to the chronic pain of arthritis, to nausea caused by cancer treatment.

U.S. government officials, however, maintain that the evidence for medical marijuana is not there. Ten states allow people to use marijuana with a doctor's prescription, but the Supreme Court has ruled that federal law trumps state law.

SOURCE: Harm Reduction Journal, October 18, 2005.

Marijuana might cause new cell growth in the brain

Fri, 14 Oct 2005 16:03:28 +0000

http://www.newscientist.com/article.ns?id=dn8155

A synthetic chemical similar to the active ingredient in marijuana makes new cells grow in rat brains. What is more, in rats this cell growth appears to be linked with reducing anxiety and depression. The results suggest that marijuana, or its derivatives, could actually be good for the brain.

In mammals, new nerve cells are constantly being produced in a part of the brain called the hippocampus, which is associated with learning, memory, anxiety and depression. Other recreational drugs, such as alcohol, nicotine and cocaine, have been shown to suppress this new growth. Xia Zhang of the University of Saskatchewan in Saskatoon, Canada, and colleagues decided to see what effects a synthetic cannabinoid called HU210 had on rats' brains.

They found that giving rats high doses of HU210 twice a day for 10 days increased the rate of nerve cell formation, or neurogenesis, in the hippocampus by about 40%.

Just like Prozac?
A previous study showed that the antidepressant fluoxetine (Prozac) also increases new cell growth, and the results indicated that it was this cell growth that caused Prozac’s anti-anxiety effect. Zhang wondered whether this was also the case for the cannabinoid, and so he tested the rats for behavioural changes.

When the rats who had received the cannabinoid were placed under stress, they showed fewer signs of anxiety and depression than rats who had not had the treatment. When neurogenesis was halted in these rats using X-rays, this effect disappeared, indicating that the new cell growth might be responsible for the behavioural changes.

In another study, Barry Jacobs, a neuroscientist at Princeton University, gave mice the natural cannabinoid found in marijuana, THC (D9-tetrahydrocannabinol)). But he says he detected no neurogenesis, no matter what dose he gave or the length of time he gave it for. He will present his results at the Society for Neuroscience meeting in Washington DC in November.

Jacobs says it could be that HU210 and THC do not have the same effect on cell growth. It could also be the case that cannabinoids behave differently in different rodent species - which leaves open the question of how they behave in humans.

Zhang says more research is needed before it is clear whether cannabinoids could some day be used to treat depression in humans.

Journal reference: Journal of Clinical Investigation (DOI:10.1172/JCI25509)

Yamn

Fri, 07 Oct 2005 04:48:26 +0000

yamn yamn yamn

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