Comic movie casting - Casting the heros and villains

[IkeaBoy]

With the principals for Daredevil pretty much cast (Affleck, Garner, duncan, Favreau, Farrell) and the rights to most major title picked up (e.g. Fantastic Four, Ghost Rider) who'd you cast or recast as some of the heros in big features.

Fantastic Four:
Dr. Doom- Jeremy Irons
Mr. Fantastic- Tim Robbins or David Duchovney
Sue Storm - Michelle Pfeiffer(need to think but she's the first that comes to mind)

Daredevil:
Nelson- Andy Richter
Daredevil- Guy Pierce

X-Men:
Gambit- Stephen Dorff